课题组前期已经成功从羽毛中提取了角蛋白，通过一系列评价证明羽毛角蛋白具有和人发角蛋白类似的止血性能。课题组继续对羽毛角蛋白的组织修复功能进行了研究，通过氧化法制备了羽毛角蛋白凝胶，考察了其皮肤修复、生物相容性、生物降解性能。

该课题是由王驹硕士主要完成。相关研究论文已被Colloids and Surfaces B: Biointerfaces接收。

Feather Keratin Hydrogel for Wound Repair: Preparation, Healing Effect and Biocompatibility Evaluation

Ju Wang¹, Shilei Hao^1,*, Tiantian Luo¹, Zhongjun Cheng^{1, 2}, Wenfeng Li¹, Feiyan Gao¹, Tingwang Guo¹, Yuhua Gong¹, Bochu Wang^1,*

Abstract

Keratins are highly attractive for wound healing due to their inherent bioactivity, biocompatibility and physical properties. However, nearly all wound healing studies have focused on human hair keratins, and the wound-repair effects andin vivobiocompatibilities of feather keratins are not clear. Feather keratins are derived from chicken feathers, which are considered to be the major waste in the poultry industry,and the quality of feather keratin is easier to control than that of human hair keratin due to human hair perming and colouring-dyeing.Thus, we extracted keratins from chicken feathers, and a feather keratin hydrogel was then prepared and used to test thein vivowound-healing properties and biocompatibility. The results indicated that feather keratins displayed wound-healing and biodegradation properties similar to those of human hair keratins and were also highly compatible with those of the tissue and devoid of immunogenicity and systematic toxicity. Collectively, these results suggested that feather keratin hydrogel could be used for biomedical applications, particularly effective wound healing.

Key words:feather keratin, hydrogel, wound healing, biocompatibility