娄德帅博士关于撒丁岛梭菌7α-羟基类固醇脱氢酶的分子改造研究结果近期发表在Protein and peptide letters杂志。相关研究中以SDR成员——撒丁岛梭菌7α-羟基类固醇脱氢酶为模型进行虚拟突变研究结构-热稳定性之间的关系，结果表明提高SDR成员compactness可以极显著地提高酶的热稳定性；HELIX位点尤其是LOOP上的位点改造在提高热稳定性的同时能够最大程度降低稳定性-活性的trade off效应。

[1]     Lou Deshuai; Tan Jun; Zhu Liancai; Ji Shunlin; Wang Bochu, The β-sheet core is the favored candidate of engineering SDR for enhancing thermostability but not for activity. Protein & Peptide Letters 2017, 24 (6), 511-516.

 [2]   Lou Deshuai; Tan Jun; Zhu Liancai; Ji Shunlin; Wang Bochu, Engineering Clostridium absonum 7α-hydroxysteroid dehydrogenase for enhancing thermostability based on flexible site and ΔΔG prediction.Protein & Peptide Letters (accepted)