三磷酸腺苷双磷酸酶属于ATP酶家族，它能水解核苷三磷酸和二磷酸的磷酸酐键。这些酶与其他磷酸水解酶相比，具有对各种抑制剂不敏感等特点。在过去的30年中apyrase在哺乳动物中被频繁研究。相比之下，尽管植物的生长与apyrase有着密切的关系，但对植物中apyrase的研究却很少。基于此，课题组综述了拟南芥中apyrase的研究进展，并指出了目前研究存在的困难及今后可能的研究方向。

本课题主要由孟润博士完成，相关研究已经于2019年1月发表于Biologia Plantarum. 63: 38-42 DOI: 10.32615/bp.2019.005

Apyrases in Arabidopsis thaliana

R. MENG, L.Q. ZHU, Y.F. YANG, L.C. ZHU, Z.K. HOU, L. JIN*, and B.C. WANG*

[ABSTRACT]Apyrases belong to the ATPase family of enzymes that hydrolyze phosphoanhydride bonds of nucleoside tri- and diphosphates. These enzymes differ markedly from other phosphohydrolases due to their high specific activity, broad divalent cation requirement, broad nucleotide substrate specificity, and insensitivity to various inhibitors. In the past 30 years, apyrases have been frequently studied in mammals. In comparison, research of apyrases in plants has received little attention, despite the growth of plants being closely related to the apyrases. In this review, we summarize the research of the apyrases in Arabidopsis thaliana and point to the possible future directions of research. Apyrases have seven members found in Arabidopsis thaliana, each with different properties and functions. Currently, the characterization and functions of AtAPY1 and AtAPY2 have been reported, though, to the best of our knowledge, the other apyrase members (AtAPY3 to 7) have not yet been sufficiently described. In this review, we also summarize the progress being made and the difficulties encountered in apyrase research in Arabidopsis thaliana.