郝石磊，男，博士，副教授，博士生导师，重庆市巴渝学者青年学者，美国麻省理工学院（Massachusetts Institute of Technology）访问学者。2011年和2014年在重庆大学分别获得药物化学专业硕士学位和生物医学工程专业博士学位。BMC Pharmacology and Toxicology、Current Pharmaceutical Design、Frontiers in Cellular Neuroscience等杂志编委和客座编辑。
研究方向：
蛋白质科学和力-生物学。主要内容包括：新型蛋白设计与产品开发（用于组织修复、止血、肿瘤等疾病的诊断和治疗），脑、胃新型药物递送系统，药物传递过程及疾病发生发展的力学效应。发表研究论文40余篇，申请发明专利3项。
研究成果：
1）主持国家自然基金和主研国家973项目，采用生物力学技术手段，阐释了脑出血后血肿应力在个体、组织和细胞水平的神经损伤过程、阈值和标志物，并开发新型脑植入剂和脑靶向药物用于脑出血治疗；作为客座编辑联合中美德法等脑出血学者在药物领域期刊《Current Pharmaceutical Design》发表了《脑出血损伤机制和治疗》的专刊；
2）率先将重组角蛋白产品用于生物医学工程领域及阐释其止血和组织修复机制，已开发重组角蛋白产品3件，正在申报产品2件；通过蛋白重组技术获得了10秒内瞬时止血及组织修复的多肽产品；
3）建立国际合作研究团队，借助QTY Code等工具进行新型蛋白质设计，包括膜蛋白、角蛋白、酶等。并成功用于肿瘤治疗、COVID-19治疗、药物递送、新蛋白材料构建、酶催化等领域。相关研究成果被MIT News, ScienceDaily等网站报道。
Shilei Hao received his PhD in Biomedical Engineering from Chongqing University, China, in 2014, and then joined in Chongqing University. Currently he is an associate professor in Department of Bioengineering of Chongqing University. His research interest focuses on:
招生方向 ：
博士研究生：生物医学工程
硕士研究生：生物医学工程、生物与医药
工作经历 (Positions Held)：
2017/09-至今 副教授 重庆大学生物工程学院 Associate Professor, Deparment of Bioengineering, CQU
2019/04-2020/04 访问学者 麻省理工学院（美国） Visiting Scientist, MIT, USA
2014/11-2017/08 讲师 重庆大学生物工程学院 Lecturer, Deparment of Bioengineering, CQU
联系方式(Contact information)：
地址：重庆大学B区生物工程学院506
Add.：506 Bioengineering building, B Campus, CQU
E-mail: shilei_hao@cqu.edu.cn; hao_shilei@126.com;
ORCID: https://orcid.org/0000-0003-1205-3102
ResearchGate: https://www.researchgate.net/profile/Shilei_Hao
学术论文(Publications)
2023
64. Meng R., Hao S* Sun C., Hou Z., Hou Y., Wang L., Deng P., Deng J., Yang Y., Xia H., Wang B.*, Qing R.*, Zhang S.* Reverse-QTY code design of active human serum albumin self-assembled amphilic nanoparticles for effective anti-tumor drug doxorubincin release in mice. Proceedings of the National Academy of Science, U.S.A. 2023, 120，e2220173120.
63.Chen, J., Wang, Y., Deng, J., Qing, R., Yang, Y., Chen, X., Gao, Z., Wang, B. Hao S* Rational design of water‐soluble, homotypic keratins self‐assembly with enhanced bioactivities. Aggregate , 2023, p.e446.
62.Zhang, H., Pan, Y., Hou, Y., Li, M., Deng, J., Wang, B.* Hao S* Smart Physical‐Based Transdermal Drug Delivery System: Towards Intelligence and Controlled Release. Small , 2023, p.2306944.
61.Sun, C., Liu, W., Wang, L., Meng, R., Deng, J.*, Qing, R., Wang, B.* Hao S* , Photopolymerized keratin-PGLa hydrogels for antibiotic resistance reversal and enhancement of infectious wound healing. Mater., Today Bio, 2023. 23, p.100807.
60.Li, W., Qing, R., Zhang, H., Wang, Z., Yuan, Y., Wang, L., Deng, J., Wang, B. Hao S* . Cellular Mechanisms Driving the Distinct Behavior of Trichocyte Keratins in Wound Healing. Advanced Functional Materials . 2023, p.2307634.
59. Li, M., Sun, H., Hou, Z., Hao S* Jin, L.* and Wang, B.*. Engineering the Physical Microenvironment into Neural Organoids for Neurogenesis and Neurodevelopment. Small , 2023, p.2306451.
58.Zhong W.; Shi D.; Zhou J., Yang Y., Wang B., Sun X., Shu Q., Li W., Xia Y., Ao L., Xiong K., Hao S* Xia H.* Role of Trichocytic Keratin in Anti-Neuroinflammatory Effect After Spinal Cord Injury. Advanced Functional Materials 2023, 30, 2212870.
57. Zhang W., Wu Q.*, Hao S* Chen S.* The hallmark and crosstalk of immune cells after intracerebral hemorrhage: immunotherapy perspectives. Frontiers in Neuroscience 2023, 16，1117999.
56. Zhai D.; Wang Y.; Yu S., Zhou J., Song J., Hao S* Chen X.* Desing and evaluation of 32P-labeled Hydroxyapatite nanoparticles fro bone tumor therapy. Drug Delivery 2023, 30, 2168791.
2022
55. Chen L.; Meng R.; Qing R.; Li W.; Wang Z.; Hou Y.; Deng J.; Pu W.; Gao Z.; Wang B.; Hao S* Bioinspiried robust keratin hydrogels for biomedical applications. Nano Letters 2022, 22,22，8835-8844.
54. Li M.; Hou Z.; Meng R..; Hao S *, Wang B.* Unraveling the potential human health risks from used disposable face mask-derived micro/nanoplastics during the COVID-19 pandemic scenario: a critical review. Environment Internation 2022, 170, 170644. .
53. Qing R.*; Hao S* Smorodine, E.; Jin D.; Zalevsky, A.; Zhang S. Preotein design: from the aspect of water solubility and stability. Chemical Reviews 2022, 122, (18), 14085-14179.
52. Wang Y.;Xu Y.; Zhang Z.; He Y.; Hou Z.; Zhao Z.; Deng J.; Qing R.*; Wang B.*; Hao S* Rational design of high-performance keratin-based hemostatic agents. Advanced Healthcare Materials 2022, 11, (15), 2200290.
51. Hou Z.; Meng R.; Chen G.; Lai T.; Qing R.; Hao S* Deng J.*; Wang B.; * Distince accumulation of nanoplastics in human intestinal organoids. Science of The Total Environment 2022, 838, 155811.
50. Tian Z.; Guo Y.; Yang X.; Guo K.; Ji J.*; Hao S* Nano calcium0deficient hyfroxyapatite/O-carboxymethyl chitisan -Cacl2 microphere loaded with rhein for bone defect repair. Journal of Bionic Engineering 2022, 19, 1087-1099.
49. Sun C.; Hao S* Wang B.* Adenosine-A2A receptor pathway in cancer immunotherapy. Fronitiers in Immunology 2022, 13, 837230.
48. Gong, Y.; Ren P.; Deng J.; Hou Z., Guo T., Hao S* Wang, B.*; Role of mass effect and thehalose on early erythrolysis after experimental intracerebral hemorrhage. Journal of Neurochemistry 2022, 160, (1), 88-99.
47. Hou Z., Li X., Ren P., Gong Y., Guo T., Krafft, R.P., Hao S* Wang B.*. Computational characterization of hemorheology in the lenticulostriate arteries predicts the location of vessel repture during hypertensive intracerebral hemorrhage. Brain Hemorrhage 2022, 3, 5-13.
2021
46. Cheng Z.; Qing R.; Hao S* Ding Y. Yin H, Zha G., Chen X., Ji J.; Wang B.; * Fabrication of ulcer-adhensive oral keratin hydrogel for gastric ulcer healing in a rat. Regenerative Biomaterials 2021, 8, (2), raba008.
45. Chen Y.; Yao Y.; Zhang J.H.; Hao S Pluripotent Cells for Stroke: From Mechanism to Therapeutic Strateges. Fronitiers in Cellular Neuroscience 2021, 15, 738240.
44. Gong Y.; Hao S* Wang B.* Mesenchymal stem cells transplantation in intracerebral hemorrhage: pplication and challenges. Fronitiers in Cellular Neuroscience 2021, 15, 653367.
43. Wang, Y.; Hou, Z.; Gong Y.; Hao S* Wang, B.*; Proteomic analysis of rat brain related to mass effect after experimental intracerebral hemorrhage. Brain Hemorrhage 2021, 2 (3), 101-105.
42. Ding Y., Meng R., Yin H. Hou Z., Sun C., Liu W., Hao S* Pan Y.* Wang B.*. Keratin-A6ACA NPs for Gastric ulcer diagnosis and repair. Journal of Materials Science: Materials in Medicine 2021, 32, (6), 1-4.
2020
41. Hao S., Jin D., Zhang S.,* and Qing R.* QTY code-designed water-soluble Fc-fusion cytokine receptors bind to their respective ligands. QRB Discovery. 2020. doi: 10.1017/qrd.2020.4
40. Chatterjee P. ∗; Jakimo N.; Lee, J.; Amrani N.; Rodr´ıguez T.; Sabrina R.T. Tysinger K.E.; Qing R.; Hao S. Sontheimer E.J.; Jacobson J.M. An engineered ScCas9 with broad PAM range and high specificity and activity. Nature Biotechnology 2020, doi.org/10.1038/s41587-020-0517-0.
39. Kan J.; Li W.; Qing R.; Gao F.; Wang Y.; Zhu L.; Wang B.; * Hao S.* Study of Mechanisms of Recombinant Keratin Solubilization with Enhanced Wound Healing Capability. Chemistry of Materials 2020, 22, 3122-3133.
38. Yang X.; Zhai D.; Song J.; Qing R.; Wang B.; Ji J.;* Chen X.;* Hao S.* Rhein-PEG- nHA conjugate as a bone targeted drug delivery vehicle for enhanced cancer chemo-radiotherapy, Nanomedicine: NBM. 2020, 27, 102196.
37. Gao F.; Li W.; Kan J.; Ding Y.; Wang Y.; Deng J.; Qing R.; Wang B.* ; Hao S. * Insight into the Regulatory Function of Human Hair Keratins in Wound Healing using Proteomics. Advanced Biosystems 2020, 1900235.
36. Gong, Y.; Wang, Y.; Qu, Q.; Hou, Z.; Guo, T.; Xu, Y.; Qing, R.; Deng, J.*; Wang, B.*; Hao S.* Nanoparticle encapsulated core-shell hydrogel for on-site BMSCs delivery protects from iron overload and enhances functional recovery. Journal of Controlled Release 2020, 320, 381-391.
35. Yang X., Tian Z., Guo K., Lu T., Ji J.,* Hao S.* Xiao S.*. Preparation and mechanism of hydroxyapatite hollow microspheres with different surface charge by biomimetic method. Journal of Materials Science: Materials in Medicine 2020, 31, 47.
34. Chen, X.; Zhai, D.; Wang, B.; Hao S. *; Song, J.*; Peng, Z.* Hair keratin promotes wound healing in rats with combined radiation-wound injury. Journal of Materials Science: Materials in Medicine 2020, 31, 28.
2019
33. Gao, F.; Li, W.; Deng, J.; Kan, J.; Guo, T.; Wang, B.; Hao, S.* Recombinant Human Hair Keratin Nanoparticles Accelerate Dermal Wound Healing. ACS Appl Mater Inter 2019, 11, (20), 18681-18690.
32. Li, W.; Gao, F.; Kan, J.; Deng, J.; Wang, B.; Hao, S.*, Synthesis and fabrication of a keratin-conjugated insulin hydrogel for the enhancement of wound healing. Colloids and Surface B 2019, 175, 436-444.
31. Lin, Q.#; Hao, S.#; Hu, W.; Wang, M.; Zang, Z.; Zhu, L.; Du, J.; Tang, X. Human hair keratin for physically transient resistive switching memory devices. Journal of Materials Chemistry C 2019, 7, (11), 3315-3321.
30. Wang, D.; Li, W.; Wang, Y.; Yin, H.; Ding, Y.; Ji, J.; Wang, B.; Hao, S.* Fabrication of an expandable keratin sponge for improved hemostasis in a penetrating trauma. Colloids and Surface B 2019, 182, 110367.
29. Zhu, Q.; Gong, Y.; Guo, T.; Deng, J.; Ji, J.; Wang, B.; Hao, S.* Thermo-sensitive keratin hydrogel against iron-induced brain injury after experimental intracerebral hemorrhage. International Journal of Pharmaceutics 2019, 566, 342-351.
28. Guo, T.; Yang, X.; Deng, J.; Zhu, L.; Wang, B.; Hao, S.* Keratin nanoparticles-coating electrospun PVA nanofibers for potential neural tissue applications. Journal of Materials Science: Materials in Medicine 2019, 30, (1), 9.
27. Guo, T.; Guo, Y.; Gong, Y.; Ji, J.; Hao, S. *; Deng, J. * Wang, B.* An enhanced charge-driven intranasal delivery of nicardipine attenuates brain injury after intracerebral hemorrhage. International Journal of Pharmaceutics 2019, 566, 46-56.
26. Gong, Y.; Gong, Y.; Hou, Z.; Guo, T.; Deng, J.; Hao, S. *; Wang, B.* Establishment of an experimental intracerebral Haemorrhage Model for Mass Effect Research using a thermo-sensitive Hydrogel.Sci Rep 2019, 9, 13838.
25. He, Y.; Qu, Q.; Luo, T.; Gong, Y.; Hou, Z.; Deng, J.; Xu, Y.; Wang, B.; Hao, S.* Engineering, Human hair keratin hydrogels alleviate rebleeding after intracerebral hemorrhage in a rat model. ACS Biomaterials Science & Engineering 2019, 5, (2), 1113-1122.
2018
24. Guo T, Ren P, Li X, Luo T, Gong Y, Hao S *， Wang B*. Neural injuries induced by hydrostatic pressure associated with mass effecy after intracerebral hemorrhage. Sci Rep . 2018; 8: 9195.
23. Cheng Z, Chen X, Zhai D, Gao F, Guo T, Li W, Hao S *，Ji J *, Wang B*. Development of keratin nanoparticles for controlled gastric mucoadhesion and drug release. Journal of Nanobiotechnology , 2018; 16:24.
22. Guo T, Li W, Wang J, Luo T, Lou D, Wang B*, Hao S *. Recombinant human hair keratin proteins for halting bleeding. Artificial Cells, Nanomedicine and Biotechnology, 2018; 46:S2. 456-461.
2017
21. Luo T, Guo T, Yang Q, Hao S *, Wang J, Cheng Z, Qu Q, He Y, Gong Y, Gao F, Li W, Xia H, Wang B*. In Situ Hydrogels Enhancing Postoperative Functional Recovery by Reducing Iron Overload after Intracerebral Haemorrhage. International Journal of Pharmaceutics 2017; 534: 179-189.
20. Hao S *, Wang B*. Review on Intracerebral Haemorrhage: Multidisciplinary Approaches to the Injury Mechanism Analysis and Therapeutic Strategies. Current Pharmaceutical Design .2017; 23: 2159-2160.
19. Luo T, Wang J, Hao S *, Guo T, Ren P, Cheng Z, Gao F, Gong Y, Wang B*. Brain Drug Delivery Systems for the Stroke intervention and recovery. Current Pharmaceutical Design .2017; 23: 2161-2176.
18. Guo T, Ren P, Hao S *, Wang B,∗. The underestimated role of mechanical stimuli in brain diseases and the related in vitro models. Current Pharmaceutical Design .2017; 23: 2258-2267.
17. Wang J, Hao S *, Luo T, Cheng Z, Li W, Gao F, Guo T, Gong Y, Wang B∗. Feather keratin hydrogel for wound repair: Preparation, healing effect and biocompatibility evaluation. Colloids and Surface B 2017, 149: 341-350 （ESI Highly Cited Papers）.
16. Wang J, Hao S*, Luo T, Zhou T, Yang X, Wang B * Keratose/poly (vinyl alcohol) blended nanofibers: Fabrication and biocompatibility assessment. Materials Science and Engineering C 2017. 72: 212–219
2016
15. Luo T, Hao S *, Chen X, Wang J, Yang Q, Wang Y, Wang B*. Development and assessment of kerateine nanoparticles for use as a hemostatic agent. Materials Science and Engineering C. 2016. 61: 352-358.
14. Wang J, Hao S*, Luo T, Yang Q, Wang B*. Development of feather keratin nanoparticles and investigation of their hemostatic efficacy. Materials Science and Engineering C .2016, 68: 768-773.
2015
13. Hao S, Wang B*, Wang Y. Density-dependent gastroretentive microparticles motion in human gastric emptying studied using computer simulation. European Journal of Pharmaceutical Science 2015; 70: 72-81
12. Hao S, Wang B*, Wang Y. Researching the dose ratio in a controlled release multiple-drug delivery system: using combination therapy with porous microparticles for the treatment of Helicobacter pylori infection. Journal of Materials Chemistry B . 2015;3(3):417-31.
11. Hao S, Wang B *, Wang Y. Porous hydrophilic core/hydrophobic shell nanoparticles for particle size and drug release control. Materials Science and Engineering C . 2015;49:51-57.
2011-2014
10. Hao S, Wang Y, Wang B*. Sinking-magnetic Microparticles Prepared by Electrospray Method for Enhanced Gastric Antimicrobial Delivery. Molecular Pharmaceutics . 2014;11(5):1640-50.
9. Hao S, Wang Y, Wang B *, Zou Q, Zeng H, Chen X, Liu X, Liu J, Yu S. A novel gastroretentive porous microparticle for anti-Helicobacter pylori therapy: Preparation, in vitro and in vivo evaluation. International Journal of Pharmaceutics .2014;463(1):10-21.
8. Hao S, Wang Y, Wang B *, Deng J, Zhu L, Cao Y. Formulation of porous poly (lactic-co-glycolic acid) microparticles by electrospray deposition method for controlled drug release. Materials Science and Engineering C . 2014;39:113-9.
7. Hao S, Wang B *, Wang Y, Xu Y. Enteric-coated sustained-release nanoparticles by coaxial electrospray: preparation, characterization, and in vitro evaluation. Journal of Nanoparticle Research 2014;16(2):1-11.
6. Hao S, Wang Y, Wang B *, Deng J, Liu X, Liu J. Rapid preparation of pH-sensitive polymeric nanoparticle with high loading capacity using electrospray for oral drug delivery. Materials Science and Engineering C.2013;33(8):4562-7.
5. Hao S, Wang B *, Wang Y, Zhu L, Wang B, Guo T. Preparation of Eudragit L 100-55 enteric nanoparticles by a novel emulsion diffusion method. Colloids and Surface B .2013;108(1):127-33.
4.Ji J *,Hao S, Dong J, Wu D, Yang B, Xu Y. Preparation, evaluation, and in vitro release study of O‐carboxymethyl chitosan nanoparticles loaded with gentamicin and salicylic acid. Journal of Applied Polymer Science . 2012;123(3):1684-9.
3. Ji J *,Hao S, Liu W, Wu D, Wang T, Xu Y. Preparation, characterization of hydrophilic and hydrophobic drug in combine loaded chitosan/cyclodextrin nanoparticles and in vitro release study. Colloids and Surface B. 2011;83(1):103-7.
2. Ji Jingou *,Hao S, Wu D, Huang R, Xu Y. Preparation, characterization and in vitro release of chitosan nanoparticles loaded with gentamicin and salicylic acid.Carbohydrate Polymers .2011;85(4):803-8.
1. Ji J *,Hao S, Liu W, Zhang J, Wu D, Xu Y. Preparation and evaluation of O-carboxymethyl chitosan/cyclodextrin nanoparticles as hydrophobic drug delivery carriers. Polymer Bulletin.2011;67(7):1201-13.
研究项目(Projects)
2018 重庆市自然科学基金，重组表达人发角蛋白及其止血机制研究（cstc2018jcyjAX0836），主持
2017 国家自然科学基金青年项目，具有干预脑出血术后铁超载和再出血功能的新型脑植入剂构建及其止血机制研究（31600770）主持
2016 国家自然科学基金面上项目，应力作用下三磷酸腺苷双磷酸酶的调节拟南芥根系生长发育 （11572063）主研
2015 中央高校基本科研业务费专项项目，个性化超早期治疗脑出血的多功能植入剂研发（106112015CDJXY230002）主持
2015 横向项目，基于小分子蛋白产品咨询及研究，主研
2014 国家重点基础研究计划（“973”）项目，脑出血后血肿应力对豆纹动脉神经复合体结构与功能的影响及其机制研究 （2014CB541603）主研
