王亚洲
中美联合培养博士，重庆大学生物工程学院教授，博士生导师。
Emai：yazhou_wang@cqu.edu.cn
主要研究方向：
1.新型纳/微药物递送系统；
2.生物力学（出血性脑卒中的生物力学问题）
3.生物材料的功能化改性及其在心血管领域的应用；
学习经历
1998.09-2002.07
湘潭大学化学化工学院食品科学与工程专业 学士
2002.09-2004.12
重庆大学生物工程学院药物化学专业 硕士
2005.03-2009.12
重庆大学生物工程学院生物医学工程专业 博士
2007.05-2008.08
美国密苏里大学哥伦比亚分校工程学院 中美联合培养博士
工作经历
2009.12-2012.09
重庆大学生物工程学院讲师
2012.09-2017.09
重庆大学生物工程学院副教授
其中2013.06-2014.06
重庆大学研究生院院长助理（挂职）
2017.09-至今
重庆大学生物工程学院 教授
近期发表的论文：
36. Edwin J Bunggulawa; Wei Wang; Tieying Yin ; Nan Wang; Colm Durkan; Yazhou Wang*; Guixue Wang, Recent advancements in the use of exosomes as drug delivery systems, Journal of Nanobiotechnology, 2018, 16: 81-93
35. Ruolin Du# ; Yazhou Wang# ; Yuhua Huang; Yinping Zhao; Dechuan Zhang; Dingyuan Du; Yuan Zhang; Zhenggong Li; Sean McGinty; Giuseppe Pontrelli; , Tieying Yin* ; Guixue Wang*, Design and testing of hydrophobic , core/hydrophilic shell nano/micro particles for drug-eluting stent coating, NPG Asia Materials 2018, 10:642-658 （共同第一作者， Feature Articles）
34. Dan Zou, Wei Wang, Daoxi Lei, Ying Yin, Peng Ren, Jinju Chen, Tieying Yin, Bochu Wang, Guixue Wang, Yazhou Wang*. Penetrate blood-brain barrier and enable anti-tumor and nerve repair in glioma by DOX-loaded monosialoganglioside micelles system. International Journal of Nanomedicine 2017, 12:4879-4889
33.Sun W, Huang Y, Yin T*, Wang J, Du R, Qiu J, Zhang Y, Wang Y*, Chen J, Wang G. Effects of elemene on inhibiting proliferation of vascular smooth muscle cells and promoting reendothelialization at the stent implantation site. Biomaterials Science 2017, 5(6), 1144-1155.
32. Yazhou Wang, Guixue Wang*. Polymeric nanomicelles: a potential hazard for the cardiovascular system? Nanomedicine, 2017, 12(12): 1355-1358
31. Yazhou Wang, Wei Wang, Zong Li, Shilei Hao & Bochu Wang, A novel perspective on neuron study: damaging and promoting effects in different neurons induced by mechanical stress, Biomech Model Mechanobiol DOI 10.1007/s10237-015-0743-4 (SCI)
30. Cao, Yang、Wang, Bochu、Wang, Yazhou、Lou, Deshuai, Polymer-controlled core-shell nanoparticles: a novel strategy for sequential drug release, RSC Advances, 2014, 4(57):30430-30439.(SCI)
29. Cao, Yang; Wang, Bochu;Wang, Yazhou; Lou, Deshuai, Dual Drug Release from Core-Shell Nanoparticles with Distinct Release Profiles, Journal of Pharmaceutical Sciences, 2014 ,103(10):3205-3216.(SCI)
28. Yazhou Wang, Zong Li, Pengyu Shao, Shilei Hao, Wei Wang, Qian Yang, Bochu Wang，A novel multiple drug release system in vitro based on adjusting swelling core of emulsion electrospun nanofibers with core–sheath structure，Materials Science and Engineering C 11/2014; 44:109–116. (SCI)
27. Hao S, Wang B,Wang Y.Porous hydrophilic core/hydrophobic shell nanoparticles for particle size and drug release control[J]. Materials Science and Engineering: C, 2015. doi:10.1016/j.msec.2014.12.029 (SCI)
26. Hao S, Wang B,Wang Y.Researching the dose ratio in a controlled release multiple-drug delivery system: using combination therapy with porous microparticles for the treatment of Helicobacter pylori infection[J]. Journal of Materials Chemistry B, 2015, 3(3): 417-431. (SCI)
25. Hao S,Wang Y,Wang B. Sinking-Magnetic Microparticles Prepared by the Electrospray Method for Enhanced Gastric Antimicrobial Delivery[J]. Molecular pharmaceutics, 2014, 11(5): 1640-1650. (SCI)
24. Hao S,Wang Y,Wang B, et al. Formulation of porous poly (lactic-co-glycolic acid) microparticles by electrospray deposition method for controlled drug release[J]. Materials Science and Engineering: C, 2014, 39: 113-119. (SCI)
23. Hao S, Wang B,Wang Y,et al. Enteric-coated sustained-release nanoparticles by coaxial electrospray: preparation, characterization, and in vitro evaluation[J]. Journal of nanoparticle research, 2014, 16(2): 1-11. (SCI)
22. Hao S,Wang Y,Wang B, et al. A novel gastroretentive porous microparticle for anti- Helicobacter pylori therapy: Preparation,in vitro and in vivoevaluation[J]. International journal of pharmaceutics, 2014, 463(1): 10-21. (SCI)
21. Yazhou Wang, Yiqiong Zhang, Bochu Wang, Yang Cao, Qingsong Yu, Tieying Yin, Fabrication of core–shell micro/nanoparticles for programmable dual drug release by emulsion electrospraying,J Nanopart Res (2013) 15:1726 (SCI)
20. Yazhou Wang, Yiqiong Zhang, Pengyu Shao, Bochu Wang, Core-shell micro/nanoparticles containing multiple drugs fabricated by emulsion electrospraying, Journal of Controlled Release 2013:172(1):e85–e86 (Abstract,SCI )
19. Shilei Hao,Yazhou Wang, Bochu Wang, Jia Deng, Xi Liu, Junyu Liu, Rapid preparation of pH-sensitive polymeric nanoparticle with high loading capacity using electrospray for oral drug delivery, Materials Science and Engineering C DOI:10.1016/j.msec.2013.07.009（SCI）
18. Lin Zhang,Yazhou Wang ,Yang Cao, Deshuai Lou, Bochu Wang, Transport barriers and strategies of anti-tumor nanocarriers delivery system, Journal of Biomedical Materials Research: Part A 2013 DOI: 10.1002/jbm.a.34635 (SCI)
17. Shilei Hao, Bochu Wang,Yazhou Wang, Liancai Zhu, Bin Wang, Tingwang Guo, Preparation of Eudragit L 100-55 enteric nanoparticles by a novel emulsion diffusion method, Colloids and Surfaces B: Biointerfaces 108 (2013) 127– 133 (SCI)
16. Deshuai Lou, Bochu Wang,Yazhou Wang, Yang Cao,Selective killing of cancer stem cells by a novel dual-targeting strategy,Medical Hypotheses 79 (2012) 430–432(SCI)
15. Wang B, Liu J, Ma LN, Xiao HL,Wang YZ, Li Y, Wang Z, Fan L, Lan C, Yang M, Hu L, Wei Y, Bian XW, Chen D, Wang J.Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44?gastric cancer cells via attenuating Wnt signaling.J Gastroenterol. 2013 Jul;48(7):798-808. (SCI)
14.Yazhou Wang,Guixue Wang, Liang Chen, Hao Li, Tieying Yin, Bochu Wang, James C-M Lee, Qingsong Yu. Electrospun nanofiber meshes with tailored architectures and patterns as potential tissue-engineering scaffolds, Biofabrication 2009 (1): 015001 (SCI)
13. Yazhou Wang, Bochu Wang, Weili Qiao, Tieying Yin, A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles, Journal of Pharmaceutical Sciences, 2010.99(12):4805-4811 (SCI)
12. Yazhou Wang, Bochu Wang, Guixue Wang, Tieying Yin, Qingsong Yu, A novel method for preparing electrospun fibers with nano-/micro-scale porous structures, Polymer Bulletin, 2009(63):259–265, (SCI)
11.Yazhou Wang,Hao Li, Guixue Wang, Tieying Yin, Bochu Wang, Qingsong Yu, Electrospinning of polymer nanofibers with ordered patterns and architectures. J. Nanosci. Nanotechnol. 10, 1699-1706 (2010); (SCI)
10.Yazhou Wang,Weili Qiao, Bochu wang, Yiqiong Zhang, Pengyu Shao, and Tieying Yin Electrospun composite nanofibers containing nanoparticles for programmable release of dual drugs, Polymer Journal, 2011.43(5): 478-483 (SCI)
9. Bochu Wang,Yazhou Wang, Tieying Yin, Qingsong Yu, Applications of electrospinning technique in drug delivery, Chemical engineering communications, 2010. 197(10):1315-1338. (SCI)
8.Yazhou Wang,Hao Li, James Lee, Qingsong Yu, Bochu Wang and Guixue Wang Modeling and Fabrication of Electrospun Polymer Nanofibers with Tailored Architectures for Tissue Engineering Scaffold Applications, Special Session: Bio-modeling and Bio-manufacturing, IEEE CIMSA 2009,226-229 (EI（20101612853172）)
7.Yazhou Wang,Qingsong Yu, Hao Li, Tieying Yin, Bochu Wang, Guixue Wang. Electrospun Nanofiber Films with Well-controlled Architectures and Patterns for Potential Tissue-engineering Applications. 2008 International Materials Research Conference SYMPOSIUM I. Biomaterials for medical application. June 9-12, 2008
6. Yiqiong Zhang, Bochu Wang,Yazhou Wang, Weili Qiao, Pengyu Shao. A novel hypurgia for cancer chemotherapy: Programmable release of antineoplastics and cytothesis agents from core–shell micro-/nano-particles. Medical Hypotheses 76 (2011) 201–203. (SCI)
5. Shao, Pengyu, Wang, Bochu,Wang, Yazhou,Li, Jun, Zhang, Yiqiong, The Application of Thermosensitive Nanocarriers in Controlled Drug Delivery, JOURNAL OF NANOMATERIALS, 2011, DOI: 10.1155/2011/389640 (SCI)
4. Weili Qiao, Bochu wang,Yazhou wang, Lichun Yang, Yiqiong Zhang, Pengyu Shao, Cancer therapy based on Nanomaterials and Nanocarrier systems, Journal of Nanomaterials, 2010 (1): 1687-4110 (SCI)
3. Jun Li, Bochu Wang,Yazhou Wang, Peng Liu, Weili Qiao. Preparation and characterization of thermosensitive nanoparticles for targeted drug delivery. Journal of Macromolecular Science, Part A Pure and Applied Chemistry, 2008, 45(10):833-838. (SCI)
2. Bochu Wang, Yang Cao, Lichun Yang,Yazhou Wang, Rheological properties of PLGA-PEG-PLGA copolymers for ophthalmic injection, Journal of Applied Polymer Science. 2011. DOI: 10.1002/app.35584 (SCI).
1. Yang Cao, Bochu Wang, Deshuai Lou,Yazhou Wang,Shilei Hao, Ling Zhang, Nanoscale delivery systems for multiply drugs combination in cancer. Future Oncology. 2011, 7(11): 1347-1357. (SCI）
承担和参与的科学研究项目
中央高校业务经费重点项目基于脑重大疾病异常微环境下神经组织损伤机制与修复研究（106112015CDJZR235514；2015-2017）项目负责人
国家自然科学基金青年基金基于肿瘤干细胞的始动性与可塑性构建时序性联合给药微纳体系及其抗肿瘤效应的研究（31200713；2013-2015年）；项目负责人；
国家重点基础研究计划（“973”）项目：“脑出血后血肿应力对豆纹动脉神经复合体结构与功能的影响及其机制研究（2014CB541603，子课题负责人）；[3]重庆市自然科学基金主动靶向肿瘤干细胞（CSCs）的联合给药微纳粒构建与抗肿瘤效应研究（cstc2012jjA0549；2012-2015年）；项目负责人；
教育部高等学校博士学科点科研基金(项目号：20120191120058；2013-2015年)项目负责人
中央高校基本科研业务费面上项目多药程序性给药纳/微粒与释药动力学模型研究（CDJZR10230006；2010-2012年）；项目负责人；
重庆市高等教育教学改革研究项目生物纳米材料的设计及应用中启迪学生的科技创新能力;项目负责人；
国家科技支撑计划新型药物缓释冠脉支架（2012BAI18B02；2012-2015年）；项目研究骨干（排名第三）;
重庆市国际科技合作项目计划（CSTC201110005; 2011-2013年）；研究研究骨干（排名第二）;
横向科研项目生物医学工程相关技术研究及技术开发；项目研究骨干（排名第二）；
相关奖励与荣誉
[1] 2010年度重庆大学优秀博士论文
[2] 2011年度重庆市优秀博士论文
[3] 2011年度重庆大学黄尚廉院士创新奖
[4]2014年度重庆大学先进工作者
